The Ultimate Diablo 4 Endgame Boss Guide: From Grigoire to Duriel
The endgame bosses guard the rarest Uniques and the most valuable crafting materials in Diablo 4. They also grant the bragging rights that separate casual adventurers from the truly obsessed.
This guide covers what you need to know about each major endgame boss. How to summon them, what they drop, and how to survive long enough to enjoy the loot. And if you ever find yourself staring at an impossible wall, check out Diablo 4 carry services to break through it.
What Are Endgame Bosses in Diablo 4?
Endgame bosses are high-tier encounters unlocked after completing the main campaign and progressing through World Tier 4 (Torment). They’re tougher than regular world bosses and require specific summoning materials, each obtained by farming other endgame activities. In short, you don’t just stumble upon these creatures—you prepare for them.
They’re also key to obtaining Mythic Uniques, those ultra-rare items with drop rates that make lottery wins look generous. Most players won’t see one without fighting these bosses repeatedly.
The Loop: How to Summon Endgame Bosses
Each boss requires a combination of materials dropped by specific enemies or found in targeted activities. The process looks roughly like this:
- Farm the materials from Helltides, Nightmare Dungeons, or other bosses.
- Craft the summoning item at an Occultist or Altar.
- Summon the boss at their unique lair.
- Defeat and repeat until you pull the gear you want.
It’s a grind, yes.
Grigoire, The Faminebearer
Location: Hall of the Penitent, Hawezar
Summoning Item: 3 Living Steel
Material Source: Living Steel chests during Helltides (rare spawn)
World Tier Required: Torment (Tier 4)
Grigoire looks like someone took the concept of pestilence and gave it an exoskeleton. His arena is a claustrophobic chapel crawling with infected husks, making movement management essential.
Fight Tips:
- Kill the adds quickly. They feed Grigoire’s area attacks.
- Save mobility skills for when he chains his AOE shockwaves.
- Cold and poison resistance help a lot.
Why Fight Him:
He’s one of the two gatekeepers to Duriel. You’ll need his drops—Demon Hearts—to craft Duriel’s summon. Grigoire also drops unique items for classes that lean on damage-over-time builds, including poison and bleed variants.
Andariel, The Maiden of Anguish
Location: Helltide-infested regions (specific altar required)
Summoning Item: 3 Pestilent Hearts
Material Source: World Bosses and Helltide Chests
World Tier Required: Torment
Andariel’s return is both nostalgic and horrifying. Her poison-heavy kit punishes stationary players, and her toxin clouds linger long enough to ruin any greedy DPS burst.
Fight Tips:
- Bring poison resistance or Elixirs of Poison Protection.
- Stay mobile—her poison nova covers wide zones.
- Watch for clone spawns during her enraged phase.
Why Fight Her:
She drops Pungent Fangs, one of the materials needed for Duriel’s summoning. Andariel also shares loot tables with Lilith for certain rare items, including class-specific Uniques that drop only from endgame bosses.
Varshan, The Consumed
Location: Malignant Burrows, Scosglen
Summoning Item: 1 Malignant Heart + 1 Black Lake Ichor
Material Source: Nightmare Dungeons and Helltides
World Tier Required: Torment
Varshan’s design looks like an anatomy lesson gone wrong—tangles of flesh, sinew, and rage. Mechanically, he’s less punishing than Grigoire but more chaotic. His tentacle summons and spreading corruption zones can fill the arena if you let the fight drag on.
Fight Tips:
- Avoid the center when the corruption phase starts.
- Use ranged skills to keep pressure on while dodging the heart explosions.
- If you get cornered, disengage immediately; the damage-over-time stacks ramp fast.
Why Fight Him:
Varshan drops Gurgling Heads, one of Duriel’s required components, along with class-specific Uniques that focus on resource regeneration and summoning builds.
Lilith, The Daughter of Hatred (Uber Lilith)
Location: Cathedral of Hatred, after completing Capstone Dungeons
Summoning Item: None (special unlock after campaign)
World Tier Required: Torment
Uber Lilith is not part of the normal boss rotation—she’s a test of patience and execution. If Grigoire and Andariel are about farming, Lilith is about mastery. Her fight has distinct phases, each designed to punish overconfidence.
Fight Tips:
- Her wing sweep in Phase 2 will one-shot you without perfect timing.
- Use movement skills to reposition after her blood explosion pattern.
- If you’re under-geared, don’t force it. The fight is designed for near-perfect builds.
Why Fight Her:
Lilith doesn’t drop unique summoning materials, but she is the gatekeeper to the game’s ultimate bragging rights. Clearing Uber Lilith is proof you’ve mastered Diablo 4’s combat system. It’s also where players test builds before pushing them into Uber Boss rotations.
Duriel, King of Maggots
Location: Pestilent Altar, Kehjistan
Summoning Item:
- 2 Pungent Fangs (Andariel)
- 2 Demon Hearts (Grigoire)
- 2 Gurgling Heads (Varshan)
- 2 Slime-Covered Innards (from Lord Zir)
Material Source: Drops from other endgame bosses
World Tier Required: Torment
Duriel, resurrected from Diablo 2 fame, is the final stop of the endgame food chain. Think of him as the blender that tests every build’s durability. His poison vomit, swarm summons, and spreading rot fields are relentless.
Fight Tips:
- You need poison resistance maxed out.
- Avoid corners; his adds can trap you easily.
- Keep damage-over-time skills active—he has high armor and resists burst.
Why Fight Him:
Duriel is the only boss with guaranteed Uber Unique drops (though still bound to RNG). His loot pool includes the most sought-after items in the game, making him the apex target for any serious player. Every item you’ve ever dreamed of—Harlequin Crest, Grandfather, Doombringer—can come from this fight.
Quick Reference Table
| Boss | Summoning Item | Key Drop | Location | Notes |
| Grigoire | 3 Living Steel | Demon Heart | Hawezar | Strong AOE, needed for Duriel |
| Andariel | 3 Pestilent Hearts | Pungent Fang | Helltide Areas | Poison-heavy fight |
| Varshan | 1 Malignant Heart + Ichor | Gurgling Head | Scosglen | Summons corruption zones |
| Lord Zir | 9 Exquisite Blood | Slime-Covered Innards | Fractured Peaks | Necrotic mechanics |
| Duriel | Combo of all above | Uber Uniques | Kehjistan | Endgame pinnacle boss |
What’s Next: The Future of Boss Hunts
Blizzard has teased additional Uber variants and potential seasonal boss rotations. The community expects new material chains in future seasons, possibly tied to region-specific events. As of now, no official details confirm additional Uber Uniques or world boss expansions, so all eyes are on the next patch notes.
Until then, Duriel reigns as the undisputed top predator of Sanctuary. Whether you fight him for loot, glory, or just the thrill of surviving, remember. Every victory is rented, and the maggots always come to collect.
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